diff --git a/py/mpconfig.h b/py/mpconfig.h
index 6056e20436..bf868624d9 100644
--- a/py/mpconfig.h
+++ b/py/mpconfig.h
@@ -448,6 +448,8 @@ typedef double mp_float_t;
     #else
       #define MP_ENDIANNESS_LITTLE (0)
     #endif
+  #elif defined(__LITTLE_ENDIAN__) || defined(__LITTLE_ENDIAN) || defined (_LITTLE_ENDIAN)
+    #define MP_ENDIANNESS_LITTLE (1)
   #elif defined(__BIG_ENDIAN__) || defined(__BIG_ENDIAN) || defined (_BIG_ENDIAN)
     #define MP_ENDIANNESS_LITTLE (0)
   #else